Human nature dictates that as long as there is money to be made or an edge to be gained, some -- not all, but certainly some -- will try to skirt the rules.
Scientific advancement dictates that chemistry will always be at least a step ahead of jurisdiction.
And so it is that, despite arguably the strongest drug testing program in professional sports, there exists some unknown percentage of Major League and Minor League players using performance-enhancing substances. To them, the threat of the penalties in place does not outweigh the temptation of chemically sophisticated shortcuts.
Perhaps, then, it's time to take another look at those penalties.